Mamajjak is a well known remedy in ayurveda for the management of madhumeha (diabetes type2). Ayurveda texts describe it as dipana-pachana (metabolic stimulant), vata-anulomaka (harmonizes neuro-endocrine activity), and tikta-paushtika (bitter-nutrient)1. All these actions are indicative of the profound effects of Mamajjak on the carbohydrate and fat metabolism. In an experimental study, Prince and Srinivasan, found that it significantly decreases the blood glucose, TBARS, SOD, CAT and GPx, in diabetic rats, which was comparable with the standard drug insulin2. Similarly, in another study, Vishwakarma et al. found that it reduces the food, water intake and glucose and AUC glucose levels and decreased the serum glucose, serum cholesterol and triglyceride levels in the diabetic rats.3 (1) Bh.P.Ni.; (2) Prince et al, Acta Pol Pharm Drug Res. 2005; 62(5): 363-367; (3) Vishwakarma et al, Ind J Exp Bio. 48: 26-30, 2010.
Mesha-shringi (Gurmar) is a widely known anti-diabetic drug of ayurveda. Ayurveda texts describe it as meha-pranut (anti-diabetic), dipana (metabolic stimulant), visha-apaham (anti-toxic), ruksha / kapha-pranut (catabolic), and tikta (bitter / anti-lipid).1 All these actions indicate its potent effects on the carbohydrate and fat metabolism. Recent studies have confirmed the hypoglycemic effect of the Meshashringi. In an experimental study, gymnemagenin and gymnemic acids present in G. sylvestre (Mesha-shringi) were seen to possess anti-hyperglycemic activity.2 In another study, the anti-hyperglycemic effect its various fractions and glycosides was reported.3 Finally, it has been concluded from the studies that it possesses anti-diabetic effect and sugar inactivation properties.3 (1) Bh.P.Ni.; (2) Sugihara et al, J. Asian Nat. Prod. Res. Vol. 2(4), pp. 321–327, 2000; (3) Patil et al, Asian J. Pharmaceut. Clin. Res. Vol. 5, Supplement 1, pp. 16–19, 2012.
Lata-karanja has been described in ayurveda as ushna-tikshna (metabolic stimulant), kapha-apaha (immuno-modulating / lowers tissue resistance to insulin), and katu (catabolic).1 Patil et al have reported significant anti- diabetic activity in this medicinal plant that was comparable with
glibenclamide.2 In another experimental study, Kunnur et al have reported anti-hyperglycemic, as well as, anti-hyperlipidemic activity in it.3 (1) Bh.P.Ni.(Chunekar); (2) Patil, D.D. et al, J. Pharmaceut. Biol., 2(10): 2750-52, 2011; (3) Kannur, DM, et al, J. Ethnopharmacol., 108: 327-31, 2006.
Katuki is an exceptionally reputed drug of ayurveda. Ayurveda texts describe it as prameha-pranut (anti-diabetic), dipni (metabolic stimulant), kapha-apha (lowers tissue resistance to insulin), tikta (bitter / anti-lipid), ruksha and laghu (catabolic), bhedini (removes the blockages in the insulin receptors on the cell membranes), dipni (metabolic stimulant), hridya (cardio-protective and cardiotoinc), and asra-pranut (blood-purifier e.g., lowers the raised cholesterol).1 All that indicates its usefulness of in the management of the diabetes mellitus and the associated metabolic disorders. An experimental study showed Katuki to increase the insulin-mediated translocation of GLUT-4 from cytosol to plasma membrane which result better glucose uptake by skeletal muscles and improved glycaemic control in diabetic rats.2 (1) Bh.P.Ni.; (2) Hussain et al, TANG, 2014 – kpubs.org
Indravaruni has been described as prameha-apaham (anti-diabetic), ushna (metabolic stimulant), tikta (anti-lipid), ama-apaham (removes the blockages In the insulin receptors on the cell membranes), visha-apaham (immuno- modulator), laghu (catabolic), kapha-apaham (lowers tissue resistance to insulin).1 In an experimental study, it exhibited significant antidiabetic activity in alloxaninduced diabetic rats. These extracts also showed improvement in such parameters like body weight, lipid profile serum creatinine, serum urea and serum protein as well as enzyme levels of liver.2 (1) Bh.P.Ni.; (2) Agrawal et al, Acta Poloniae Pharmaceutica ñ Drug Research, Vol. 69(1): 1 pp. 75ñ79, 2012.
Pippali has been described as prameha-hara (anti-diabetic), dipani and agni-vardhini (metabolic stimulant), rasayani (immuno-modulator), katuka (pungent / anti-lipid), laghu (catabolic), medo-vinashini and kapha-vinashini (lowers tissue resistance to insulin).1 The anti-hyperglycemic and anti-lipidperoxidative effects of ethanolic extract of Piper longum dried fruits in alloxaninduced diabetic rats were studied2. The blood glucose level, carbohydrate metabolizing enzymes and the status of lipid peroxidation and antioxidants were assayed using specific colorimetric methods. Oral administration of dried fruits has shown significant anti-hyperglycemic, anti-lipidperoxidative and antioxidant effects in diabetic rats comparable to that of the standard reference drug glibenclamide.3 In an experimental study, it has been seen to have bioavailability enhancing activity.4 (1) Bh.P.Ni.; (2) Dhar et al, Ind. J. Exp. Bio., 6: 232- 235. 66, 1968; (3) Manoharan et al, J. Biol. Sci., 7(1), 161-168, 2007; (4) Khajuria A., I. J. Exp. Biol. 36(1): 46-50, 1998.
Rakta-marich is a potent metabolic stimulant. Ayurveda texts describe it as ushna (metabolic stimulant), katu (pungent stimulant), tikshna (stimulant), ruksha (anti- dyslipidemic), and advocate its use in agnimandya (low BMR, as in hypothyroidism), hridroga (heart diseases), medoroga (obesity), ama-dosha (metabolic / immunologic disorders), vata-roga (neuro- endocrine disorders), kapha-rogas (immunological diseases) etc.1,2,3,4 In a research study on human volunteers, Weerapan et al, found that capsicum might have clinical implications in the management of type 2 diabetes as 5 grams of it presented capsaicin blood levels that were associated with a decrease in plasma glucose levels and the maintenance of insulin levels.5 Earlier,
Akiba Y. et al had reported the discovery of TPRV1 on the beta cells of pancreas and found that capsaicin could activate this receptor resulting in an increase in insulin secretion.6 In an experimental study Islam et al found that red chilli is insulinotropic rather than hypoglycemic.7 (1) Sharma P.V., D.G.V. Part II; (2) Arya Bhishak; (3) Siddha Bheshaj Manimala; (4) Ayurveda Vigyan; (5) Weerapan et al, J. Med. Assoc. Thai., Vol.: 92(1), 2009; (6) Akiba Y, et al., Biochem. Biophys. Res. Commun. 321: 219-25 2004; 7. Md Shahidul Islam et al, Phytotherapy Res., Vol 22(8), pp. 1025-1029,2008.
On the basis of the individual actions of its ingredients, Glycie tablet is used as an adjuvant in the management of:
- Diabetes type 2 (madhumeha, sthula pramehi);
- Gynecological disorders (stri-rogas) – PCOD (beeja-kosha granthi);
- Dyslipidemia (medo-dushti) – raised cholesterol and TGL and low HDL in the blood;
- Atherosclerosis (dhamani-pratichaya) – CAD (hrid-dhamani roga), peripheral vascular disease (dhamani-pratichaya), retinal exudates (netra-patala medo-samchaya), especially resulting diabetes.
Initial dose – 1-2 tabs thrice a day; Maint. dose – ½-1 tab once / twice a day; To be taken just after / within meals, with water.
Avoid during pregnancy, children below 6 yrs, bleeding disorders, and along with anticoagulants. Regular blood test for BT, CT, PT is must for long-term use. In case of any signs of bleeding, or prolonged BT, CT, PT, and abnormal PTI, stop Thyrin at once and manage accordingly.